Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Trientine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.92 |
| ▸ | CA6 | P23280 | 5/20 | 0.92 |
| ▸ | CA7 | P43166 | 5/20 | 0.92 |
| ▸ | CA9 | Q16790 | 5/20 | 0.92 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.92 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.92 |
| ▸ | CA2 | P00918 | 4/20 | 0.92 |
| ▸ | CA4 | P22748 | 4/20 | 0.92 |
| ▸ | CA5A | P35218 | 4/20 | 0.92 |
| ▸ | LMNA | P02545 | 3/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.92 |
| ▸ | CA3 | P07451 | 3/20 | 0.92 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.92 |
| ▸ | CA1 | P00915 | 2/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.92 |
| ▸ | TP53 | P04637 | 1/20 | 0.92 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.85 |
| ▸ | MEN1 | O00255 | 2/20 | 0.83 |
| ▸ | RECQL | P46063 | 2/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trientine SCHEMBL11208570 | 1.00 | CA12 (0.92) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL9746122 | 1.00 | CA12 (0.92) | CA12CA6CA7CA9CA14 | |
| SCHEMBL581603 | 0.96 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| SCHEMBL181401 | 0.96 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL10917234 | 0.96 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| SCHEMBL25340653 | 0.96 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL3840289 | 0.96 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| SCHEMBL25342018 | 0.96 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| Trientine SCHEMBL15439 | 0.96 | CA12 (1.00) | CA12CA6CA7CA9CA14 | |
| SCHEMBL25342922 | 0.96 | CA12 (1.00) | CA12CA6CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117129297-B | Method for manufacturing standard light sheet of single-particle lunar soil sample | 中国科学院地质与地球物理研究所 | 2024-01-26 | — | — | CN | claimed |
| CN-117129297-A | Method for manufacturing standard light sheet of single-particle lunar soil sample | 中国科学院地质与地球物理研究所 | 2023-11-28 | — | — | CN | claimed |
| EP-0721436-A4 | STABILIZED, HIGH SOLIDS, LOW VISCOSITY SMECTITE SLURRIES, AND METHOD OF PREPARATION | LAPORTE INDUSTRIES LTD (GB) | 1996-12-18 | — | — | EP | claimed |
| EP-0721436-A1 | STABILIZED, HIGH SOLIDS, LOW VISCOSITY SMECTITE SLURRIES, AND METHOD OF PREPARATION | Laporte Industries Limited (GB) | 1996-07-17 | — | — | EP | claimed |
| WO-1995009135-A1 | STABILIZED, HIGH SOLIDS, LOW VISCOSITY SMECTITE SLURRIES, AND METHOD OF PREPARATION | LAPORTE INDUSTRIES LIMITED (GB) | 1995-04-06 | — | — | WO | claimed |
| CN-117129297-B | Method for manufacturing standard light sheet of single-particle lunar soil sample | 中国科学院地质与地球物理研究所 | 2024-01-26 | — | — | CN | disclosed |
| CN-117129297-A | Method for manufacturing standard light sheet of single-particle lunar soil sample | 中国科学院地质与地球物理研究所 | 2023-11-28 | — | — | CN | disclosed |
| US-4708812-A | HEAT STORAGE MATERIALS FOR USE IN SOLAR HEATING DEVICES | UNION CARBIDE CORPORATION (US) | 1987-11-24 | — | — | US | disclosed |