SCHEMBL8944348

SCHEMBL8944348

O=C1CCC2C(=CC=C3C=CC=CC32)N1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 1/20 0.31
CRBN Q96SW2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11712536 0.76
SCHEMBL11467730 0.74
SCHEMBL6565013 0.71
SCHEMBL30241698 0.70 CRBN (0.37) DDB1CRBN
SCHEMBL6247864 0.69 MAPT (0.36)
SCHEMBL6249438 0.66
SCHEMBL5453261 0.65
SCHEMBL6247033 0.65
SCHEMBL7418012 0.62
Acetone SCHEMBL28873728 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0724440-A4 DI- AND TETRA-HYDROBENZO F]QUINOLIN-3-ONES SMITHKLINE BEECHAM CORP (US) 1996-11-20 EP disclosed
EP-0724440-A4 DI- AND TETRA-HYDROBENZO F]QUINOLIN-3-ONES SMITHKLINE BEECHAM CORP (US) 1996-11-20 EP disclosed
CN-1133007-A Di- and tetra-hydrobenzo[F] quinolin-3-ones SMITHKLINE BEECHAM CORP (US) 1996-10-09 CN disclosed
EP-0724440-A1 DI- AND TETRA-HYDROBENZO F]QUINOLIN-3-ONES SMITHKLINE BEECHAM CORPORATION (US) 1996-08-07 EP disclosed
EP-0724440-A1 DI- AND TETRA-HYDROBENZO F]QUINOLIN-3-ONES SMITHKLINE BEECHAM CORPORATION (US) 1996-08-07 EP disclosed
WO-1995005821-A1 DI- AND TETRA-HYDROBENZO[F]QUINOLIN-3-ONES SMITHKLINE BEECHAM CORPORATION (US) 1995-03-02 WO disclosed
WO-1995005821-A1 DI- AND TETRA-HYDROBENZO[F]QUINOLIN-3-ONES SMITHKLINE BEECHAM CORPORATION (US) 1995-03-02 WO disclosed