SCHEMBL8944614

SCHEMBL8944614

O=C(Cc1ccccc1F)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc32)cc1

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 5/20 0.60
AVPR1A P37288 5/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7344569 0.89 AVPR2 (0.65) AVPR2AVPR1A
SCHEMBL7330829 0.89 AVPR1A (0.63) AVPR2AVPR1A
SCHEMBL7338055 0.84 AVPR2 (0.66) AVPR2AVPR1A
SCHEMBL7335347 0.83 AVPR2 (0.74) AVPR2AVPR1A
SCHEMBL7329745 0.82 AVPR2 (0.62) AVPR2AVPR1A
SCHEMBL7340480 0.81 AVPR2 (0.70) AVPR2AVPR1A
SCHEMBL8313271 0.80 AVPR2 (0.77) AVPR2AVPR1A
SCHEMBL8944376 0.79 AVPR2 (0.59) AVPR2AVPR1A
SCHEMBL7340007 0.79 AVPR2 (0.58) AVPR2AVPR1A
SCHEMBL8405733 0.78 AVPR1A (0.55) AVPR2AVPR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5516774-A TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER AMERICAN CYANAMID COMPANY (US) 1996-05-14 US claimed