SCHEMBL8944757

SCHEMBL8944757

CCOC(=O)CCC(=O)NC1CC(C)(C)NC(C)(C)C1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.56
POLB P06746 4/20 0.48
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
MAPT P10636 1/20 0.48
RECQL P46063 1/20 0.48
SMYD3 Q9H7B4 1/20 0.48
ALDH1A1 P00352 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
HTT P42858 2/20 0.46
USP2 O75604 1/20 0.45
KDM4E B2RXH2 1/20 0.45
PKM P14618 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9153534 0.86 GAA (0.60) GAAPOLBKMT2AMEN1MAPT
SCHEMBL2901212 0.86 GAA (0.71) GAAPOLBKMT2AMEN1MAPT
SCHEMBL9836848 0.85 GAA (0.58) GAAPOLBKMT2AMEN1MAPT
SCHEMBL4094277 0.81 GAA (0.65) GAAPOLBKMT2AMEN1MAPT
SCHEMBL11475878 0.81 MEN1 (0.43) GAAPOLBKMT2AMEN1MAPT
SCHEMBL14885793 0.80 GAA (0.48) GAAPOLBKMT2AMEN1MAPT
SCHEMBL10559499 0.80 GAA (0.63) GAAPOLBKMT2AMEN1MAPT
SCHEMBL10991852 0.80 KMT2A (0.52) GAAPOLBKMT2AMEN1MAPT
SCHEMBL1647940 0.79 GAA (0.67) GAAPOLBKMT2AMEN1MAPT
SCHEMBL9715150 0.79 GAA (0.56) GAAPOLBKMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578731-A ASYMMETRICAL HYDRAZINE DERIVATIVE CIBA-GEIGY CORPORATION (US) 1996-11-26 US disclosed
US-5554754-A PHOTOSTABILIZERS CIBA-GEIGY CORPORATION (US) 1996-09-10 US disclosed
US-5470980-A Light stabilizers for polymers that can be grafted to polymers CIBA-GEIGY CORPORATION (US) 1995-11-28 US disclosed
EP-0647626-A1 Azadicarboxylic acid derivatives containing hindered amine moieties as polymer stabilisers CIBA-GEIGY AG (CH) 1995-04-12 EP disclosed
US-5352719-A Blended with synthetic or natural polymers ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-10-04 US disclosed
US-5319090-A Benzotriazole and oxanilide UV absorber hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-06-07 US disclosed
US-5233047-A Benzotriazole UV absorber hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1993-08-03 US disclosed
US-5116976-A HINDERED AMINE LIGHT STABILIZER HYDRAZIDES ATOCHEM NORTH AMERICA, INC (US) 1992-05-26 US disclosed
EP-0467344-A1 Hindered amine light stabilizer hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1992-01-22 EP disclosed
US-5041545-A 2-hydroxybenzophenone hydrazides and derivatives thereof ATOCHEM NORTH AMERICA, INC. (US) 1991-08-20 US disclosed