Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 4/20 | 0.34 |
| ▸ | PPARD | Q03181 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622272 | 1.00 | EED (0.40) | EEDPOLBLTA4HMEN1KMT2A | |
| SCHEMBL8624889 | 0.91 | EED (0.39) | EEDPOLBMEN1KMT2ANPSR1 | |
| SCHEMBL8624891 | 0.91 | EED (0.39) | EEDPOLBMEN1KMT2ANPSR1 | |
| SCHEMBL8624698 | 0.86 | PTPN1 (0.40) | EEDPOLBMEN1KMT2ANR1I2 | |
| SCHEMBL8624693 | 0.86 | PTPN1 (0.40) | EEDPOLBMEN1KMT2ANR1I2 | |
| SCHEMBL8624984 | 0.83 | EED (0.40) | EEDPOLBNPSR1GAAALDH1A1 | |
| SCHEMBL8624983 | 0.83 | EED (0.40) | EEDPOLBNPSR1GAAALDH1A1 | |
| SCHEMBL8625391 | 0.82 | S1PR1 (0.41) | — | |
| SCHEMBL8625397 | 0.82 | S1PR1 (0.41) | — | |
| SCHEMBL8619951 | 0.81 | PTPN1 (0.38) | EEDNPSR1GAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |