Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDFT1 | P37268 | 4/20 | 0.54 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.46 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23752399 | 0.94 | FDFT1 (0.60) | FDFT1ACP3 | |
| SCHEMBL8621199 | 0.94 | FDFT1 (0.60) | FDFT1ACP3 | |
| SCHEMBL8946999 | 0.94 | FDFT1 (0.60) | FDFT1ACP3 | |
| SCHEMBL8619710 | 0.91 | S1PR2 (0.58) | S1PR2S1PR4S1PR1S1PR3HDAC1 | |
| SCHEMBL8625400 | 0.91 | S1PR2 (0.58) | S1PR2S1PR4S1PR1S1PR3HDAC1 | |
| SCHEMBL8618777 | 0.87 | FDFT1 (0.47) | FDFT1ACP3 | |
| SCHEMBL8621425 | 0.86 | FDFT1 (0.50) | FDFT1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL8621508 | 0.85 | FDFT1 (0.49) | FDFT1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL8622304 | 0.84 | FDFT1 (0.58) | FDFT1S1PR2S1PR4S1PR1S1PR3 | |
| SCHEMBL8621086 | 0.83 | FDFT1 (0.56) | FDFT1S1PR2S1PR4S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | claimed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0595635-A1 | Alpha-phosphorous substituted sulfonate derivatives as squalene synthetase inhibitors | E.R. Squibb & Sons, Inc. (US) | 1994-05-04 | — | — | EP | disclosed |