Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SQLE | Q14534 | 5/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.63 |
| ▸ | ICMT | O60725 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620468 | 1.00 | SQLE (0.78) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL8624130 | 1.00 | SQLE (0.78) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL8620471 | 1.00 | SQLE (0.78) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL8624135 | 1.00 | SQLE (0.78) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL9168757 | 1.00 | SQLE (0.78) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL6768879 | 0.98 | SQLE (0.81) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL8618704 | 0.98 | SQLE (0.81) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL8618707 | 0.98 | SQLE (0.81) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL6768881 | 0.98 | SQLE (0.81) | SQLEKMT2AMAPTMEN1CYP3A4 | |
| SCHEMBL24940909 | 0.91 | SQLE (0.80) | SQLEKMT2AMAPTMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |