Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13144463 | 0.83 | MAPK1 (0.62) | KDM4EGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8283407 | 0.81 | TDP1 (0.71) | KDM4EGAALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8947242 | 0.80 | KMT2A (0.67) | KDM4EGAALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8432669 | 0.78 | POLB (0.62) | KDM4EGAALMNAKMT2AMEN1 | |
| SCHEMBL22106531 | 0.78 | NPC1 (0.58) | KDM4EGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL8957109 | 0.77 | KDM4E (0.61) | KDM4EGAASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8947318 | 0.77 | KMT2A (0.67) | KDM4EGAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8947325 | 0.77 | SMN1; SMN2 (0.57) | KDM4EGAALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL3259703 | 0.77 | KDM4E (0.61) | KDM4EGAALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10528940 | 0.76 | KDM4E (0.66) | KDM4EGAALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |