Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947157 | 0.74 | MAPK1 (0.53) | MAPK1NPC1TP53LMNAALDH1A1 | |
| SCHEMBL20996785 | 0.71 | CA12 (0.57) | MAPK1LMNAALDH1A1MAPTCA12 | |
| SCHEMBL11925429 | 0.70 | CA12 (0.56) | MAPK1LMNAALDH1A1MAPTCA12 | |
| SCHEMBL11925424 | 0.70 | CA12 (0.56) | MAPK1LMNAALDH1A1MAPTCA12 | |
| SCHEMBL8947294 | 0.70 | MAPK1 (0.61) | MAPK1ALDH1A1TSHRKDM4EPOLB | |
| SCHEMBL403798 | 0.69 | CA1 (0.68) | TP53LMNAALDH1A1MAPTCA12 | |
| SCHEMBL11778347 | 0.69 | MAPK1 (0.69) | MAPK1LMNAALDH1A1MAPTTSHR | |
| SCHEMBL8947156 | 0.69 | MAPK1 (0.60) | MAPK1ALDH1A1MAPTTSHRKDM4E | |
| SCHEMBL20996786 | 0.67 | KDM4E (0.56) | MAPK1LMNAALDH1A1MAPTCA12 | |
| SCHEMBL20518663 | 0.67 | MAPK1 (1.00) | MAPK1ALDH1A1TSHRKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |