Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17204573 | 0.90 | TP53 (0.71) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL15595269 | 0.88 | KMT2A (0.78) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL13039963 | 0.88 | KMT2A (0.69) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL29802080 | 0.88 | KMT2A (0.78) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL17038574 | 0.87 | KMT2A (0.64) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL8178988 | 0.87 | PDE4A (0.71) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL15595277 | 0.87 | KMT2A (0.68) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL17204605 | 0.86 | SMPD1 (0.67) | KMT2AMEN1TP53PDE4APDE4B | |
| SCHEMBL28336482 | 0.84 | KMT2A (0.57) | KMT2AMEN1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL28333735 | 0.84 | PDE4B (0.69) | KMT2AMEN1TP53SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105085429-B | Aromatic heterocyclic derivative and application thereof in medicines | 广东东阳光药业有限公司 | 2019-12-10 | — | — | CN | disclosed |
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |