Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947932 | 0.87 | DPP4 (0.54) | DPP4KCNA5KCNH2TACR1MAPK8 | |
| SCHEMBL8948120 | 0.85 | DPP4 (0.52) | DPP4KCNA5KCNH2TACR1MAPK8 | |
| SCHEMBL8947969 | 0.85 | DPP4 (0.52) | DPP4KCNA5KCNH2TACR1MAPK8 | |
| SCHEMBL8948082 | 0.85 | DPP4 (0.54) | DPP4TACR1MAPK8 | |
| SCHEMBL8948090 | 0.85 | DPP4 (0.54) | DPP4TACR1MAPK8 | |
| SCHEMBL8458434 | 0.85 | DPP4 (0.52) | DPP4TACR1MAPK8 | |
| SCHEMBL8948056 | 0.84 | DPP4 (0.51) | DPP4KCNA5KCNH2TACR1MAPK8 | |
| SCHEMBL8948088 | 0.84 | DPP4 (0.52) | DPP4TACR1MAPK8 | |
| SCHEMBL8947901 | 0.83 | DPP4 (0.49) | DPP4KCNA5KCNH2TACR1MAPK8 | |
| SCHEMBL9233934 | 0.81 | DPP4 (0.49) | DPP4KCNA5KCNH2TACR1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5527811-A | CALCIUM- AND SUBSTANCE P RECEPTOR-ANTAGONIST ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | claimed |
| EP-0634402-A1 | Isochinolinone derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1995-01-18 | — | — | EP | claimed |
| US-5527811-A | CALCIUM- AND SUBSTANCE P RECEPTOR-ANTAGONIST ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0634402-A1 | Isochinolinone derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1995-01-18 | — | — | EP | disclosed |