Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1D | Q01668 | 2/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8949992 | 0.93 | CACNA1F (0.47) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E | |
| SCHEMBL8949808 | 0.91 | CACNA1D (0.51) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E | |
| SCHEMBL2647704 | 0.89 | CACNA1F (0.56) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E | |
| SCHEMBL8950009 | 0.85 | CACNA1F (0.46) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E | |
| SCHEMBL27310185 | 0.85 | CACNA1F (0.52) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E | |
| SCHEMBL2662903 | 0.83 | CACNA1F (0.50) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E | |
| SCHEMBL2648819 | 0.82 | CACNA1F (0.70) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E | |
| SCHEMBL9229958 | 0.81 | CACNA1F (0.59) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E | |
| SCHEMBL9363639 | 0.81 | CACNA1D (0.41) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E | |
| SCHEMBL8949606 | 0.81 | CACNA1F (0.48) | CACNA1DCACNA1FCACNA1SCACNA1CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502057-A | Polysubstituted pyridines useful for treating lipoproteinanaemia and arteriosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1996-03-26 | — | — | US | disclosed |
| US-5470982-A | Disubstituted pyridines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-11-28 | — | — | US | disclosed |
| US-5173495-A | 7-[(2,6-dialkyl-4-furyl or thienyl-pyridyl)]-3,5-di-(dihydroxy-6-enoates) useful for treating circulatory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 1992-12-22 | — | — | US | disclosed |
| US-4968689-A | Certain 2,6-diisopropyl-4-(4-fluoro-phenyl)-3,5-bis-dimethyl-3',5'-dihydroxy-hept-6-enoate-pyridine derivatives useful for treating lipoproteinaemia and arteriosclerosis | BAYER AKTIENGESELLSCHAFT (DE) | 1990-11-06 | — | — | US | disclosed |