Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8952967 | 1.00 | HMGCR (0.39) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL8952734 | 0.92 | HMGCR (0.38) | HMGCR | |
| SCHEMBL8952740 | 0.92 | HMGCR (0.38) | HMGCR | |
| SCHEMBL8953274 | 0.92 | HMGCR (0.38) | HMGCR | |
| SCHEMBL8953283 | 0.92 | HMGCR (0.38) | HMGCR | |
| SCHEMBL8953118 | 0.91 | HMGCR (0.41) | HMGCR | |
| SCHEMBL8953125 | 0.91 | HMGCR (0.41) | HMGCR | |
| SCHEMBL8952905 | 0.88 | NPSR1 (0.40) | HMGCR | |
| SCHEMBL8952911 | 0.88 | NPSR1 (0.40) | HMGCR | |
| SCHEMBL8952726 | 0.88 | ESR1 (0.36) | HMGCRESR1CHRM1TBXA2RPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5506219-A | ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-04-09 | — | — | US | disclosed |