Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895349 | 1.00 | KCNH2 (0.46) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 | |
| SCHEMBL20952269 | 0.92 | KCNH2 (0.46) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 | |
| SCHEMBL895411 | 0.92 | KCNH2 (0.46) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 | |
| SCHEMBL474772 | 0.90 | KCNH2 (0.49) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 | |
| SCHEMBL27966125 | 0.90 | KCNH2 (0.49) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 | |
| SCHEMBL30065583 | 0.90 | KCNH2 (0.49) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 | |
| SCHEMBL474732 | 0.90 | KCNH2 (0.48) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 | |
| SCHEMBL28947735 | 0.90 | KCNH2 (0.48) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 | |
| SCHEMBL16309224 | 0.89 | KCNH2 (0.52) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 | |
| SCHEMBL894831 | 0.88 | KCNH2 (0.45) | KCNH2HCRTR1HCRTR2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150246917-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2015-09-03 | — | — | US | disclosed |
| US-8871759-B2 | Inhibitors of hepatitis C virus replication | MERCK SHARP & DOHME CORP. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20120083483-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP (NJ) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083483-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | KCNH2 4621/4885HCRTR1 4044/4885HCRTR2 4504/4885 |
| US-20150246917-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | KCNH2 4621/4885HCRTR1 4044/4885HCRTR2 4504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.