Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 12/20 | 0.38 |
| ▸ | CTRC | Q99895 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22344929 | 0.88 | CMA1 (0.47) | KCNH2CMA1CTRCCYP3A4CYP2C9 | |
| SCHEMBL895419 | 0.88 | CMA1 (0.47) | KCNH2CMA1CTRCCYP3A4CYP2C9 | |
| SCHEMBL10222777 | 0.87 | KCNH2 (0.46) | KCNH2CMA1CTRCCYP3A4CYP2C9 | |
| SCHEMBL10224165 | 0.83 | KCNH2 (0.47) | KCNH2CMA1CTRCCYP3A4CYP2C9 | |
| SCHEMBL10222681 | 0.83 | KCNH2 (0.57) | KCNH2CMA1CTRCCYP3A4CYP2C9 | |
| SCHEMBL896043 | 0.83 | KCNH2 (0.57) | KCNH2CMA1CTRCCYP3A4CYP2C9 | |
| SCHEMBL896081 | 0.83 | KCNH2 (0.39) | KCNH2CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL474880 | 0.83 | KCNH2 (0.40) | KCNH2CMA1CTRCCYP3A4CYP2C9 | |
| SCHEMBL10223093 | 0.82 | KCNH2 (0.52) | KCNH2CMA1CTRCCYP3A4CYP2C9 | |
| SCHEMBL10224239 | 0.80 | CMA1 (0.49) | KCNH2CMA1CTRCCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11053243-B2 | Inhibitors of hepatitis C virus replication | MERCK SHARP & DOHME CORP. (US) | 2021-07-06 | — | — | US | disclosed |
| US-20200262836-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2020-08-20 | — | — | US | disclosed |
| US-8871759-B2 | Inhibitors of hepatitis C virus replication | MERCK SHARP & DOHME CORP. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20120083483-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP (NJ) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200262836-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | KCNH2 4621/4885CMA1 920/4885CTRC 239/4885 |
| US-20120083483-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | KCNH2 4621/4885CMA1 920/4885CTRC 239/4885 |
| US-11053243-B2 | Inhibitors of hepatitis C virus replication | HAVCR2, HCCS, EIF2AK2 | KCNH2 4621/4885CMA1 920/4885CTRC 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.