Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9673260 | 0.92 | CXCR4 (0.46) | CHRNA7EGLN1CXCR4 | |
| SCHEMBL9672362 | 0.90 | CXCR4 (0.46) | CHRNA7EGLN1CXCR4 | |
| SCHEMBL9742041 | 0.90 | CHRNA7 (0.44) | CHRNA7EGLN1CXCR4FNTAFNTB | |
| SCHEMBL12836268 | 0.87 | CXCR4 (0.46) | CXCR4FNTAFNTBHTR2AHTR2C | |
| SCHEMBL9934555 | 0.86 | FNTA (0.53) | CXCR4KCNH2FNTAFNTBHTR2A | |
| SCHEMBL9933651 | 0.86 | FNTA (0.53) | CXCR4KCNH2FNTAFNTBHTR2A | |
| SCHEMBL9963450 | 0.82 | CXCR4 (0.46) | EGLN1CXCR4OPRL1KCNH2 | |
| SCHEMBL9933633 | 0.81 | FNTA (0.45) | FNTAFNTB | |
| SCHEMBL9965950 | 0.80 | FNTA (0.51) | EGLN1CXCR4KCNH2FNTAFNTB | |
| SCHEMBL9932907 | 0.80 | FNTA (0.51) | EGLN1CXCR4KCNH2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456279-B1 | Condensed piperidine derivatives, intermediates and process for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1996-01-03 | — | — | EP | disclosed |
| EP-0306356-B1 | CONDENSED PIPERIDINE DERIVATIVES, INTERMEDIATES AND PROCESS FOR THEIR PREPARATION , THEIR USE AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-05-19 | — | — | EP | disclosed |
| US-5126353-A | Also used as analgesics, diuretics, hypotensive agents, antiischemic agents | ROUSSEL UCLAF (FR) | 1992-06-30 | — | — | US | disclosed |
| EP-0456279-A1 | Condensed piperidine derivatives, intermediates and process for their preparation, their use as medicaments and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1991-11-13 | — | — | EP | disclosed |
| US-4927832-A | DIURETIC, ANTIARRYTHMIA, ANTIISCHEMIC, HYPOTENSIVE | ROUSSEL UCLAF (FR) | 1990-05-22 | — | — | US | disclosed |
| EP-0306356-A1 | Condensed piperidine derivatives, intermediates and process for their preparation , their use as medicaments and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1989-03-08 | — | — | EP | disclosed |