Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | PLA2G4B | P0C869 | 4/20 | 0.58 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.57 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.54 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.53 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8955720 | 1.00 | TSHR (0.65) | TSHRPLA2G4BSMPD1GGPS1NR5A1 | |
| SCHEMBL8955762 | 0.98 | TSHR (0.62) | TSHRPLA2G4BSMPD1GGPS1NR5A1 | |
| SCHEMBL8955723 | 0.96 | TSHR (0.60) | TSHRPLA2G4BSMPD1GGPS1NR5A1 | |
| SCHEMBL8955681 | 0.96 | TSHR (0.65) | TSHRPLA2G4BSMPD1GGPS1NR5A1 | |
| SCHEMBL8955665 | 0.95 | TSHR (0.62) | TSHRPLA2G4BSMPD1GGPS1NR5A1 | |
| SCHEMBL8956143 | 0.95 | TSHR (0.57) | TSHRPLA2G4BSMPD1NR5A1THRB | |
| SCHEMBL4568921 | 0.93 | KMT2A (0.58) | TSHRPLA2G4BSMPD1GGPS1THRA | |
| SCHEMBL4568928 | 0.91 | KMT2A (0.60) | TSHRPLA2G4BSMPD1GPBAR1KMT2A | |
| SCHEMBL3905859 | 0.91 | TSHR (0.76) | TSHRPLA2G4BSMPD1GGPS1NR5A1 | |
| SCHEMBL4208924 | 0.91 | TSHR (0.76) | TSHRPLA2G4BSMPD1GGPS1NR5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516767-A | PRODRUG AS HYPOGLYCEMIC AGENT | SANDOZ LTD. (CH) | 1996-05-14 | — | — | US | disclosed |
| US-5412137-A | Hypoglycemic agents | SANDOZ LTD. (CH) | 1995-05-02 | — | — | US | disclosed |