Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 6/20 | 0.58 |
| ▸ | FNTB | P49356 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | TACR1 | P25103 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9142783 | 0.93 | FNTA (0.60) | FNTAFNTBKMT2AMEN1TACR1 | |
| SCHEMBL8783447 | 0.87 | FNTA (0.53) | FNTAFNTBKMT2AMEN1TACR1 | |
| SCHEMBL8788673 | 0.86 | FNTA (0.52) | FNTAFNTBKMT2AMEN1TACR1 | |
| SCHEMBL9139914 | 0.86 | FNTA (0.52) | FNTAFNTBKMT2AMEN1TACR1 | |
| SCHEMBL8895688 | 0.84 | FNTA (0.51) | FNTAFNTBKMT2AMEN1TACR1 | |
| SCHEMBL8894524 | 0.84 | TACR1 (0.51) | FNTAFNTBKMT2AMEN1TACR1 | |
| SCHEMBL8894203 | 0.84 | TACR1 (0.51) | FNTAFNTBKMT2AMEN1TACR1 | |
| SCHEMBL8956981 | 0.83 | FNTA (0.62) | FNTAFNTBKMT2AMEN1TACR1 | |
| SCHEMBL8893745 | 0.83 | FNTA (0.49) | FNTAFNTBKMT2AMEN1TACR1 | |
| SCHEMBL8956909 | 0.81 | TACR1 (0.67) | FNTAFNTBKMT2AMEN1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484804-A | Perhydroisoindole derivatives as antagonists of substance P | RHONE-POULENC RORER S.A. (FR) | 1996-01-16 | — | — | US | disclosed |
| US-5463077-A | Exhibit substance P antagonist activity | RHONE-POULENC RORER S.A. (FR) | 1995-10-31 | — | — | US | disclosed |