SCHEMBL8957286

SCHEMBL8957286

C=CCOC(=O)c1ccccc1NCl

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.70
ALDH1A1 P00352 4/20 0.60
TSHR P16473 4/20 0.60
HSD17B10 Q99714 3/20 0.60
LIG1 P18858 1/20 0.43
LMNA P02545 2/20 0.43
RHOA P61586 1/20 0.43
KMT2A Q03164 3/20 0.41
MEN1 O00255 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
ADRB2 P07550 1/20 0.41
ADRB1 P08588 1/20 0.41
ADRB3 P13945 1/20 0.41
KDM4E B2RXH2 4/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
POLB P06746 1/20 0.40
ATM Q13315 1/20 0.40
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2460812 0.84 CYP3A4 (0.70) CYP3A4ALDH1A1TSHRHSD17B10LIG1
SCHEMBL27901950 0.83 CYP3A4 (0.68) CYP3A4ALDH1A1TSHRHSD17B10LIG1
SCHEMBL15174 0.83 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRHSD17B10LIG1
SCHEMBL27474785 0.83 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRHSD17B10LIG1
SCHEMBL29362146 0.83 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRHSD17B10LIG1
SCHEMBL16371573 0.83 CYP3A4 (1.00) CYP3A4ALDH1A1TSHRHSD17B10LIG1
Vinyl Chloride SCHEMBL8855429 0.82 CYP3A4 (0.89) CYP3A4ALDH1A1TSHRHSD17B10LIG1
Ethylene SCHEMBL11883084 0.81 CYP3A4 (0.96) CYP3A4ALDH1A1TSHRHSD17B10LIG1
SCHEMBL11394440 0.81 CYP3A4 (0.96) CYP3A4ALDH1A1TSHRHSD17B10LIG1
Phosphine SCHEMBL28202216 0.81 CYP3A4 (0.96) CYP3A4ALDH1A1TSHRHSD17B10LIG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5557005-A Process for preparing 3-chloroanthranilic alkyl esters of high purity from 3-chloroanthranilic acid HOECHST AKTIENGESELLSCHAFT (DE) 1996-09-17 US disclosed
US-4306074-A Preparation of a mixture of an alkyl 3-chloroanthranilate and an alkyl 6-chloroanthranilate BASF AKTIENGESELLSCHAFT (DE) 1981-12-15 US disclosed