SCHEMBL8958465

SCHEMBL8958465

CCCCCc1ccc(C)c2c3nc4nc(nc5[nH]c(nc6nc(nc([nH]3)c12)-c1ccccc1-6)c1ccccc51)-c1ccccc1-4

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 5/20 0.39
KDM4E B2RXH2 4/20 0.39
CYP3A4 P08684 2/20 0.39
CYP1A2 P05177 2/20 0.39
TSHR P16473 1/20 0.39
LMNA P02545 2/20 0.34
HTT P42858 2/20 0.34
MEN1 O00255 1/20 0.34
POLB P06746 1/20 0.34
KMT2A Q03164 1/20 0.34
HPGD P15428 4/20 0.33
ALDH1A1 P00352 3/20 0.33
GAA P10253 2/20 0.33
MAPT P10636 2/20 0.33
USP2 O75604 1/20 0.33
GLA P06280 1/20 0.33
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33
NPSR1 Q6W5P4 2/20 0.33
XBP1 P17861 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1449413 0.87 KDM4E (0.38) HSD17B10KDM4ECYP3A4CYP1A2TSHR
SCHEMBL7536961 0.86 NR1H2 (0.38) HSD17B10KDM4ECYP3A4CYP1A2TSHR
SCHEMBL5157116 0.86 NR1H2 (0.38) HSD17B10KDM4ECYP3A4CYP1A2TSHR
SCHEMBL6510089 0.86 NR1H2 (0.38) HSD17B10KDM4ECYP3A4CYP1A2TSHR
SCHEMBL6512213 0.86 NR1H2 (0.38) HSD17B10KDM4ECYP3A4CYP1A2TSHR
SCHEMBL6513226 0.86 NR1H2 (0.38) HSD17B10KDM4ECYP3A4CYP1A2TSHR
SCHEMBL9566102 0.85 NR1H2 (0.37) HSD17B10KDM4ECYP3A4CYP1A2TSHR
SCHEMBL4957428 0.83 KDM4E (0.41) HSD17B10KDM4ECYP3A4CYP1A2TSHR
SCHEMBL8958264 0.83 HSD17B10 (0.44) HSD17B10KDM4ECYP3A4CYP1A2TSHR
Ciaftalan SCHEMBL11520284 0.82 MEN1 (0.39) HSD17B10KDM4ECYP3A4CYP1A2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5582774-A PHTHALOCYANINE DERIVATIVE MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1996-12-10 US disclosed
US-5446141-A Optical recording media, filters, liquid crystals display MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1995-08-29 US disclosed
US-5024926-A Heat, light, weather resistance; for optical recording media, filters, liquid crystal displays MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1991-06-18 US disclosed
EP-0337209-A2 Alkylphthalocyanine near-infrared absorbers and recording/display materials using the same MITSUI TOATSU CHEMICALS, Inc. (JP) 1989-10-18 EP disclosed