SCHEMBL8958844

SCHEMBL8958844

C=CCN1CCN(CC=C)C(=O)C1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.46
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
NPSR1 Q6W5P4 1/20 0.36
CASP3 P42574 1/20 0.35
ADRA1D P25100 1/20 0.33
ADRA1A P35348 1/20 0.33
ADRA1B P35368 1/20 0.33
POLB P06746 1/20 0.33
CA12 O43570 1/20 0.32
CA2 P00918 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15348021 0.87 HDAC3 (0.37) CYP3A4HDAC3HDAC4HDAC1HDAC7
SCHEMBL11493479 0.85 HDAC3 (0.36) CYP3A4HDAC3HDAC4HDAC1HDAC7
SCHEMBL462082 0.84 CYP3A4 (0.46) CYP3A4HDAC3HDAC4HDAC1HDAC7
SCHEMBL29082944 0.84 CYP3A4 (0.46) CYP3A4HDAC3HDAC4HDAC1HDAC7
SCHEMBL9603599 0.84 HDAC3 (0.35) CYP3A4HDAC3HDAC4HDAC1HDAC7
SCHEMBL11493591 0.82 HDAC3 (0.40) CYP3A4HDAC3HDAC4HDAC1HDAC7
SCHEMBL29472099 0.81 CYP3A4 (0.39) CYP3A4HDAC3HDAC4HDAC1HDAC7
SCHEMBL5139880 0.81
SCHEMBL10774202 0.81 HDAC3 (0.40) CYP3A4HDAC3HDAC4HDAC1HDAC7
SCHEMBL5519257 0.80 CYP3A4 (0.42) CYP3A4HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8059631-A None JP disclosed
JP-H0859631-A PRODUCTION OF 1,4-DIALKYL-2,3-PIPERAZINEDIONES MITSUI TOATSU CHEM INC 1996-03-05 JP disclosed
US-5002701-A Iodine and Halide Complex of a Pyrazinedicarboxylic Acid RESEARCH FRONTIERS INCORPORATED (US) 1991-03-26 US disclosed