Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.72 |
| ▸ | HTR2A | P28223 | 6/20 | 0.72 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | KRAS | P01116 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959574 | 1.00 | HTR2C (0.72) | HTR2CHTR2ANTSR1PRMT5HTR7 | |
| SCHEMBL7253595 | 0.87 | HTR2C (0.55) | HTR2CHTR2APRMT5HTR7 | |
| SCHEMBL7253589 | 0.87 | HTR2C (0.55) | HTR2CHTR2APRMT5HTR7 | |
| SCHEMBL7253587 | 0.87 | HTR2C (0.55) | HTR2CHTR2APRMT5HTR7 | |
| SCHEMBL12474064 | 0.87 | HTR2C (0.77) | HTR2CHTR2ANTSR1PRMT5HTR7 | |
| SCHEMBL8959875 | 0.84 | HTR2C (1.00) | HTR2CHTR2ANTSR1HTR7 | |
| SCHEMBL9232987 | 0.84 | HTR2C (1.00) | HTR2CHTR2ANTSR1HTR7 | |
| SCHEMBL8959885 | 0.84 | HTR2C (1.00) | HTR2CHTR2ANTSR1HTR7 | |
| SCHEMBL22930137 | 0.83 | HTR2C (0.70) | HTR2CHTR2ANTSR1PRMT5HTR7 | |
| SCHEMBL848269 | 0.83 | HTR2A (0.61) | HTR2CHTR2ANTSR1PRMT5HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |