Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.59 |
| ▸ | HTR2A | P28223 | 8/20 | 0.59 |
| ▸ | CDK4 | P11802 | 3/20 | 0.52 |
| ▸ | CCND1 | P24385 | 3/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8959697 | 0.87 | HTR2A (0.48) | HTR2CHTR2ACDK4CCND1P2RX7 | |
| Fumaric Acid SCHEMBL8959686 | 0.87 | HTR2A (0.48) | HTR2CHTR2ACDK4CCND1P2RX7 | |
| SCHEMBL5991839 | 0.87 | HTR2C (0.54) | HTR2CHTR2ACDK4CCND1P2RX7 | |
| SCHEMBL28651148 | 0.86 | HTR2C (0.59) | HTR2CHTR2ACDK4CCND1P2RX7 | |
| SCHEMBL25310410 | 0.82 | HTR2C (0.55) | HTR2CHTR2ACDK4CCND1P2RX7 | |
| SCHEMBL31561786 | 0.82 | HTR2C (0.55) | HTR2CHTR2ACDK4CCND1P2RX7 | |
| SCHEMBL7323037 | 0.82 | HTR2C (0.55) | HTR2CHTR2ACDK4CCND1P2RX7 | |
| SCHEMBL18856959 | 0.82 | HTR2C (0.59) | HTR2CHTR2ACDK4CCND1P2RX7 | |
| SCHEMBL18857021 | 0.82 | HTR2C (0.55) | HTR2CHTR2ACDK4CCND1P2RX7 | |
| SCHEMBL6789563 | 0.80 | PRKCI (0.56) | HTR2CHTR2ACDK4CCND1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | claimed |
| JP-7149723-A | — | — | None | — | — | JP | disclosed |
| CN-113372347-A | Beta-carboline derivatives and their use as indoleamine-2, 3-dioxygenase 1 inhibitors | 南京医科大学 | 2021-09-10 | — | — | CN | disclosed |
| CN-113307806-A | Beta-carboline selective monoamine oxidase B inhibitor and pharmaceutical application thereof | 陈冬寅 | 2021-08-27 | — | — | CN | disclosed |
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |
| JP-H07149723-A | 1-AMINOETHYLINDOLE DERIVATIVE | F HOFFMANN LA ROCHE AG | 1995-06-13 | — | — | JP | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |