Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2849458 | 1.00 | KDM4E (0.33) | KDM4EALDH1A1MAPTEPHX1 | |
| SCHEMBL8960784 | 1.00 | KDM4E (0.33) | KDM4EALDH1A1MAPTEPHX1 | |
| SCHEMBL220206 | 0.78 | EPHX1 (0.40) | EPHX1 | |
| SCHEMBL3150105 | 0.78 | EPHX1 (0.40) | EPHX1 | |
| SCHEMBL3150097 | 0.78 | EPHX1 (0.40) | EPHX1 | |
| SCHEMBL9619211 | 0.75 | EPHX1 (0.50) | KDM4EALDH1A1MAPTEPHX1 | |
| SCHEMBL11159369 | 0.74 | — | — | |
| SCHEMBL9603587 | 0.72 | KDM4E (0.36) | KDM4EALDH1A1MAPT | |
| SCHEMBL31274100 | 0.72 | POLB (0.31) | — | |
| SCHEMBL8960761 | 0.71 | CETP (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0388778-B1 | Preparation of dioxolane derivatives | HOFFMANN LA ROCHE (CH) | 1996-01-10 | — | — | EP | claimed |
| US-5283346-A | Chemical intermediate for vitamin e | HOFFMANN-LA ROCHE INC. (US) | 1994-02-01 | — | — | US | claimed |
| EP-0388778-B1 | Preparation of dioxolane derivatives | HOFFMANN LA ROCHE (CH) | 1996-01-10 | — | — | EP | disclosed |
| US-5283346-A | Chemical intermediate for vitamin e | HOFFMANN-LA ROCHE INC. (US) | 1994-02-01 | — | — | US | disclosed |
| US-5232852-A | Enzymatic hydrolysis utilizing a lipase | HOFFMANN-LA ROCHE INC. (US) | 1993-08-03 | — | — | US | disclosed |
| EP-0388778-A2 | Preparation of dioxolane derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1990-09-26 | — | — | EP | disclosed |