Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 17/20 | 0.59 |
| ▸ | TK1 | P04183 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8955967 | 0.83 | PNP (0.72) | PNP | |
| SCHEMBL27519441 | 0.76 | PNP (0.70) | PNPTK1BLMUSP2TSHR | |
| SCHEMBL9235491 | 0.76 | PNP (0.70) | PNPTK1BLMUSP2TSHR | |
| SCHEMBL1938289 | 0.76 | PNP (0.73) | PNPTK1HSP90AA1HSP90AB1 | |
| SCHEMBL1935860 | 0.75 | PNP (0.71) | PNPTK1BLMUSP2TSHR | |
| SCHEMBL8955206 | 0.74 | PNP (1.00) | PNP | |
| SCHEMBL9434934 | 0.74 | PNP (0.70) | PNPTK1BLMUSP2TSHR | |
| SCHEMBL8955531 | 0.73 | PNP (0.70) | PNP | |
| SCHEMBL8961586 | 0.73 | PNP (0.65) | PNP | |
| SCHEMBL10507619 | 0.73 | PNP (0.72) | PNPBLMUSP2TSHREDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0465297-B1 | 9-Purinyl phosphonic acid derivatives | MERRELL DOW PHARMA (US) | 1996-01-31 | — | — | EP | claimed |
| EP-0465297-A1 | 9-Purinyl phosphonic acid derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | claimed |
| EP-0465297-B1 | 9-Purinyl phosphonic acid derivatives | MERRELL DOW PHARMA (US) | 1996-01-31 | — | — | EP | disclosed |
| EP-0465297-A1 | 9-Purinyl phosphonic acid derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |