Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gluconic Acid SCHEMBL872998 | 0.93 | PDE4A (0.83) | PDE4ATP53LMNAUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL30528009 | 0.93 | PDE4A (0.83) | PDE4ATP53LMNAUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL27466658 | 0.93 | PDE4A (0.83) | PDE4ATP53LMNAUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL5095328 | 0.91 | PDE4A (0.79) | PDE4ATP53LMNAUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL27816908 | 0.91 | PDE4A (0.79) | PDE4ATP53LMNAUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL4091887 | 0.91 | PDE4A (0.79) | PDE4ATP53LMNAUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL20298871 | 0.91 | PDE4A (0.79) | PDE4ATP53LMNAUSP2SLCO1B1 | |
| SCHEMBL5238369 | 0.91 | PDE4A (0.85) | PDE4ALMNAUSP2SLCO1B1TSHR | |
| SCHEMBL13219455 | 0.91 | PDE4A (0.85) | PDE4ALMNAUSP2SLCO1B1TSHR | |
| SCHEMBL16609882 | 0.91 | PDE4A (0.85) | PDE4ALMNAUSP2SLCO1B1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538738-A | OLIGOESTERS OF HYDROXYCARBOXYLIC ACIDS, ACRYLATED OLIGOESTERS, CROSSLINKING | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1996-07-23 | — | — | US | disclosed |
| US-5244628-A | Polylactones, polyesters | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1993-09-14 | — | — | US | disclosed |