Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL776297 | 0.91 | TSHR (0.38) | CYP2C19LMNATDP1HPGDKDM4E | |
| Hydrochloric Acid SCHEMBL11163950 | 0.89 | CYP2C19 (0.36) | CYP2C19LMNATDP1HPGDKDM4E | |
| SCHEMBL6135444 | 0.81 | MAPT (0.40) | CYP2C19SRCCYP2D6LMNATDP1 | |
| SCHEMBL6971134 | 0.74 | CYP1A2 (0.46) | CYP2C19SRCCYP2D6LMNAMAPK1 | |
| SCHEMBL6740830 | 0.72 | CYP2D6 (0.44) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL622284 | 0.71 | CYP1A2 (0.57) | CYP2C19SRCCYP2D6LMNAMAPK1 | |
| SCHEMBL21119246 | 0.71 | CYP1A2 (0.57) | CYP2C19SRCCYP2D6LMNAMAPK1 | |
| SCHEMBL12833352 | 0.71 | CYP1A2 (0.57) | CYP2C19SRCCYP2D6LMNAMAPK1 | |
| SCHEMBL1335927 | 0.71 | CYP1A2 (0.47) | CYP2C19SRCCYP2D6LMNAMAPK1 | |
| SCHEMBL8414774 | 0.70 | CYP2D6 (0.42) | SRCCYP2D6LMNAMAPK1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695437-A1 | PHOTOCURABLE COMPOSITIONS | THE DOW CHEMICAL COMPANY (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5464538-A | Reverse osmosis membrane | THE DOW CHEMICAL COMPANY (US) | 1995-11-07 | — | — | US | disclosed |
| WO-1994024609-A2 | PHOTOCURABLE COMPOSITIONS | THE DOW CHEMICAL COMPANY (US) | 1994-10-27 | — | — | WO | disclosed |
| US-5310581-A | Photoresists, reacting photolabile onium with a photoreactive nucleophile, modified vinylbenzyl chloride polymer | THE DOW CHEMICAL COMPANY (US) | 1994-05-10 | — | — | US | disclosed |
| US-5238747-A | Compounds with onium groups cured with compound having nucleophilic groups; photoresists release agents | THE DOW CHEMICAL COMPANY (US) | 1993-08-24 | — | — | US | disclosed |