SCHEMBL8962864

SCHEMBL8962864

COCc1ccc(C2CCC([C@H]3CC[C@H](/C=C/Cl)CC3)CC2)cc1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 1/20 0.35
ESR2 Q92731 7/20 0.33
ESR1 P03372 6/20 0.33
CYP3A4 P08684 2/20 0.33
CYP2C9 P11712 2/20 0.33
SPHK1 Q9NYA1 2/20 0.31
TEAD1 P28347 1/20 0.31
MAOA P21397 2/20 0.31
MAOB P27338 2/20 0.31
CYP2D6 P10635 1/20 0.31
CARM1 Q86X55 1/20 0.30
PRMT6 Q96LA8 1/20 0.30
LSS P48449 1/20 0.30
HRH3 Q9Y5N1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8963203 0.96 HDAC2 (0.38) HDAC2ESR2ESR1CYP3A4CYP2C9
SCHEMBL8963207 0.96 HDAC2 (0.38) HDAC2ESR2ESR1CYP3A4CYP2C9
SCHEMBL8962953 0.92 HDAC2 (0.35) HDAC2ESR2ESR1CYP3A4CYP2C9
SCHEMBL8962947 0.92 HDAC2 (0.35) HDAC2ESR2ESR1CYP3A4CYP2C9
SCHEMBL8962878 0.89 ESR2 (0.39) HDAC2ESR2ESR1CYP3A4CYP2C9
SCHEMBL8962882 0.89 ESR2 (0.39) HDAC2ESR2ESR1CYP3A4CYP2C9
SCHEMBL8727099 0.87 HDAC2 (0.36) HDAC2ESR2ESR1CYP3A4CYP2C9
SCHEMBL8727103 0.87 HDAC2 (0.36) HDAC2ESR2ESR1CYP3A4CYP2C9
SCHEMBL8727113 0.87 HDAC2 (0.36) HDAC2ESR2ESR1CYP3A4CYP2C9
SCHEMBL8727106 0.87 HDAC2 (0.36) HDAC2ESR2ESR1CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0559860-B1 HALOVINYL-DERIVATIVES HOFFMANN LA ROCHE (CH) 1996-02-14 EP disclosed
US-5364556-A Halovinyl-derivatives HOFFMANN-LA ROCHE INC. (US) 1994-11-15 US disclosed
WO-1993007234-A1 HALOVINYL-DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1993-04-15 WO disclosed