SCHEMBL8965439

SCHEMBL8965439

COC(=O)CNC(COCc1cc(C)cc(C)c1)C(c1ccccc1)c1ccccc1

nearest known ligand 0.81

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.81
CACNA1F O60840 3/20 0.81
CACNA1D Q01668 3/20 0.81
CACNA1S Q13698 3/20 0.81
CACNA1C Q13936 3/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8910724 0.92 TACR1 (0.83) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9543467 0.88 TACR1 (0.73) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8879167 0.87 TACR1 (0.61) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8910627 0.85 TACR1 (0.86) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8827091 0.84 TACR1 (0.80) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8827093 0.84 TACR1 (0.80) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8965316 0.84 TACR1 (1.00) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8912110 0.83 TACR1 (0.78) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8923781 0.83 TACR1 (1.00) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
Oxalic Acid SCHEMBL8911634 0.83 TACR1 (0.69) TACR1CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593557-B1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME (GB) 1996-01-31 EP claimed
EP-0593557-A1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY. MERCK SHARP & DOHME (GB) 1994-04-27 EP claimed
WO-1993001160-A1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME LIMITED (GB) 1993-01-21 WO claimed
EP-0522808-A2 Aromatic compounds, pharmaceutical compositions containing them and their use in therapy MERCK SHARP & DOHME LTD. (GB) 1993-01-13 EP claimed