Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 8/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966003 | 0.93 | PRKCQ (0.53) | PRKCQPRKCDGSK3BSCD5NAPEPLD | |
| SCHEMBL15930692 | 0.92 | PRKCQ (0.59) | PRKCQPRKCDGSK3BNAPEPLDRPS6KB1 | |
| SCHEMBL8965919 | 0.89 | PRKCQ (0.55) | PRKCQBRD4PRKCDGSK3BNAPEPLD | |
| SCHEMBL15930694 | 0.88 | PRKCQ (0.60) | PRKCQPRKCDGSK3BSCDSCD5 | |
| SCHEMBL15930693 | 0.88 | PRKCQ (0.52) | PRKCQPRKCDGSK3BSCD5NAPEPLD | |
| SCHEMBL15930701 | 0.87 | PRKCQ (0.59) | PRKCQPRKCDGSK3BCYP2D6 | |
| SCHEMBL8966162 | 0.87 | PRKCQ (0.53) | PRKCQPRKCDCYP11B2GSK3BNAPEPLD | |
| SCHEMBL15930691 | 0.86 | PRKCQ (0.56) | PRKCQPRKCDGSK3BNAPEPLDRPS6KB1 | |
| SCHEMBL8966170 | 0.86 | PRKCQ (0.52) | PRKCQBRD4PRKCDGSK3BCYP2D6 | |
| SCHEMBL15930702 | 0.85 | PRKCQ (0.54) | PRKCQPRKCDGSK3BNAPEPLDRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-07 | — | — | US | disclosed |
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | PRKCQ 38/4885BRD4 1026/4885BRD2 1456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.