Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 7/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967787 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDRPS6KB1ALDH1A1GSK3B | |
| SCHEMBL8968077 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDRPS6KB1ALDH1A1GSK3B | |
| SCHEMBL8968022 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDRPS6KB1ALDH1A1GSK3B | |
| SCHEMBL8966867 | 0.88 | PRKCQ (0.48) | PRKCQPRKCDRPS6KB1ALDH1A1GSK3B | |
| SCHEMBL9014976 | 0.84 | PRKCQ (0.65) | PRKCQPRKCDRPS6KB1PRKCA | |
| SCHEMBL8967419 | 0.83 | PRKCQ (0.54) | PRKCQPRKCDALDH1A1PRKCAKDM4E | |
| SCHEMBL8966800 | 0.82 | PRKCQ (0.49) | PRKCQPRKCDRPS6KB1ALDH1A1GSK3B | |
| SCHEMBL8967368 | 0.81 | PRKCQ (0.48) | PRKCQPRKCDRPS6KB1ALDH1A1GSK3B | |
| SCHEMBL8967927 | 0.81 | PRKCQ (0.48) | PRKCQPRKCDRPS6KB1ALDH1A1GSK3B | |
| SCHEMBL8967937 | 0.81 | PRKCQ (0.48) | PRKCQPRKCDRPS6KB1ALDH1A1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-07 | — | — | US | disclosed |
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | PRKCQ 38/4885PRKCD 120/4885RPS6KB1 401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.