Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PGK1 | P00558 | 1/20 | 0.34 |
| ▸ | PGK2 | P07205 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6550363 | 0.88 | MAPT (0.42) | TSHRPPARDMAPTMAPK1TDP1 | |
| SCHEMBL29159494 | 0.83 | TSHR (0.44) | TSHRPPARDMAPTMAPK1TP53 | |
| SCHEMBL816257 | 0.83 | TSHR (0.44) | TSHRPPARDMAPTMAPK1TP53 | |
| SCHEMBL21828165 | 0.81 | TSHR (0.43) | TSHRPPARDMAPTMAPK1TP53 | |
| SCHEMBL21805451 | 0.78 | CHRM1 (0.54) | TSHRPPARDMAPTMAPK1TDP1 | |
| SCHEMBL14561058 | 0.78 | FOLH1 (0.55) | TSHRPPARDMAPTMAPK1TDP1 | |
| SCHEMBL4435559 | 0.78 | MAPT (0.41) | TSHRPPARDMAPTMAPK1TP53 | |
| SCHEMBL12925134 | 0.77 | TSHR (0.39) | TSHRPPARDMAPTMAPK1TDP1 | |
| SCHEMBL15032899 | 0.76 | TSHR (0.52) | TSHRPPARDMAPTMAPK1TP53 | |
| SCHEMBL9343304 | 0.75 | MAPT (0.45) | TSHRPPARDMAPTMAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5523430-A | Protein farnesyl transferase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-04 | — | — | US | disclosed |