Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 13/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 7/20 | 0.36 |
| ▸ | PRKCA | P17252 | 6/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8968285 | 0.93 | PRKCQ (0.49) | PRKCQGSK3BALDH1A1RPS6KB1PRKCD | |
| SCHEMBL8968269 | 0.93 | PRKCQ (0.49) | PRKCQGSK3BALDH1A1RPS6KB1PRKCD | |
| SCHEMBL8968114 | 0.93 | PRKCQ (0.49) | PRKCQGSK3BALDH1A1RPS6KB1PRKCD | |
| SCHEMBL8968518 | 0.93 | PRKCQ (0.47) | PRKCQALDH1A1RPS6KB1PRKCDPRKCA | |
| SCHEMBL8968254 | 0.87 | GSK3B (0.43) | PRKCQGSK3BALDH1A1RPS6KB1PRKCD | |
| SCHEMBL9010561 | 0.84 | PRKCQ (0.60) | PRKCQRPS6KB1PRKCDPRKCAPRKCB | |
| SCHEMBL15930710 | 0.82 | PRKCQ (0.57) | PRKCQGSK3BALDH1A1PRKCDPRKCA | |
| SCHEMBL8967599 | 0.81 | PRKCQ (0.56) | PRKCQALDH1A1PRKCDPRKCAPRKCB | |
| SCHEMBL9012860 | 0.81 | PRKCQ (0.61) | PRKCQRPS6KB1PRKCDPRKCAPRKCB | |
| SCHEMBL8968639 | 0.80 | PRKCQ (0.47) | PRKCQALDH1A1PRKCDPRKCAPRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-08-07 | — | — | US | disclosed |
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221334-A1 | KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | PRKCQ 38/4885GSK3B 152/4885ALDH1A1 4211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.