Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 14/20 | 0.53 |
| ▸ | PRKCA | P17252 | 2/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.53 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8970354 | 0.93 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHSD17B14BMPR1B | |
| SCHEMBL8970311 | 0.92 | PRKCQ (0.52) | PRKCQPRKCAPRKCDHSD17B14BMPR1B | |
| SCHEMBL8970308 | 0.92 | PRKCQ (0.52) | PRKCQPRKCAPRKCDHSD17B14BMPR1B | |
| SCHEMBL8970317 | 0.91 | PRKCQ (0.51) | PRKCQPRKCAPRKCDHSD17B14BMPR1B | |
| SCHEMBL8969842 | 0.91 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHSD17B14BMPR1B | |
| SCHEMBL9007436 | 0.90 | PRKCQ (0.69) | PRKCQPRKCAPRKCDPRKCI | |
| SCHEMBL9013243 | 0.90 | PRKCQ (0.53) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL8970341 | 0.90 | PRKCQ (0.52) | PRKCQPRKCAPRKCDHSD17B14BMPR1B | |
| SCHEMBL8970007 | 0.90 | PRKCQ (0.55) | PRKCQPRKCAPRKCDHSD17B14 | |
| SCHEMBL9010917 | 0.89 | PRKCQ (0.67) | PRKCQPRKCAPRKCDPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |