Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 13/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 2/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969853 | 0.93 | KDM4E (0.49) | PRKCQPOLBPRKCAPRKCDGBA1 | |
| SCHEMBL8970084 | 0.92 | PRKCQ (0.49) | PRKCQPRKCAPRKCDGBA1KDM4E | |
| SCHEMBL9008256 | 0.91 | PRKCQ (0.47) | PRKCQPRKCAPRKCDGBA1KDM4E | |
| SCHEMBL8969861 | 0.88 | PRKCQ (0.64) | PRKCQPOLBPRKCAPRKCDKDM4E | |
| SCHEMBL13857181 | 0.84 | KDM4E (0.51) | PRKCQPOLBPRKCAPRKCDGBA1 | |
| SCHEMBL8970034 | 0.84 | PRKCQ (0.49) | PRKCQPRKCAPRKCDKDM4ESMN1; SMN2 | |
| SCHEMBL1481470 | 0.83 | PRKCQ (0.49) | PRKCQPRKCAPRKCDKDM4ESMN1; SMN2 | |
| SCHEMBL8969876 | 0.82 | PRKCQ (0.53) | PRKCQPRKCAPRKCD | |
| SCHEMBL8969884 | 0.82 | PRKCQ (0.53) | PRKCQPRKCAPRKCDKDM4ESMN1; SMN2 | |
| SCHEMBL9010401 | 0.82 | PRKCQ (0.53) | PRKCQPRKCAPRKCDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |