Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 20/20 | 0.56 |
| ▸ | PRKCA | P17252 | 8/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 8/20 | 0.53 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11993703 | 1.00 | PRKCQ (0.56) | PRKCQPRKCAPRKCDPRKCBFLT3 | |
| SCHEMBL8965474 | 0.89 | PRKCQ (0.70) | PRKCQPRKCAPRKCDPRKCBFLT3 | |
| SCHEMBL8965771 | 0.89 | PRKCQ (0.67) | PRKCQPRKCAPRKCDPRKCBFLT3 | |
| SCHEMBL11993712 | 0.86 | PRKCQ (0.56) | PRKCQPRKCAPRKCDPRKCBFLT3 | |
| SCHEMBL8970582 | 0.86 | PRKCQ (0.60) | PRKCQPRKCAPRKCDPRKCBFLT3 | |
| SCHEMBL11993707 | 0.86 | PRKCQ (0.60) | PRKCQPRKCAPRKCDPRKCBFLT3 | |
| SCHEMBL11993719 | 0.85 | PRKCQ (0.62) | PRKCQPRKCAPRKCDPRKCBFLT3 | |
| SCHEMBL11993717 | 0.84 | PRKCQ (0.52) | PRKCQPRKCAPRKCDPRKCBFLT3 | |
| SCHEMBL11993718 | 0.84 | PRKCQ (0.52) | PRKCQPRKCAPRKCDPRKCBFLT3 | |
| SCHEMBL11993716 | 0.84 | PRKCQ (0.52) | PRKCQPRKCAPRKCDPRKCBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |