SCHEMBL8970921

SCHEMBL8970921

CC(C)Oc1cccc(CC(=O)N2CCCC(OCC[N+]34CCC(Cc5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TACR2 P21452 1/20 0.51
TACR1 P25103 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8969597 0.92 TACR2 (0.53) TACR2TACR1
Water SCHEMBL8559085 0.88 TACR1 (0.48) TACR2TACR1
SCHEMBL8562105 0.85 TACR1 (0.54) TACR2TACR1
SCHEMBL8564434 0.82 TACR1 (0.51) TACR2TACR1
Nolpitantium SCHEMBL29388081 0.80 TACR2 (0.62) TACR2TACR1
Nolpitantium SCHEMBL6350205 0.80 TACR2 (0.62) TACR2TACR1
Nolpitantium SCHEMBL2142512 0.80 TACR2 (0.62) TACR2TACR1
Nolpitantium SCHEMBL1650319 0.80 TACR2 (0.61) TACR2TACR1
Nolpitantium SCHEMBL29405138 0.80 TACR2 (0.61) TACR2TACR1
Nolpitantium SCHEMBL7561842 0.80 TACR2 (0.61) TACR2TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0700386-A1 NEUROKININ RECEPTOR ANTAGONISTS SANOFI (FR) 1996-03-13 EP claimed
WO-1995026338-A1 NEUROKININ RECEPTOR ANTAGONISTS SANOFI (FR) 1995-10-05 WO claimed
EP-0700386-A1 NEUROKININ RECEPTOR ANTAGONISTS SANOFI (FR) 1996-03-13 EP disclosed
WO-1995026338-A1 NEUROKININ RECEPTOR ANTAGONISTS SANOFI (FR) 1995-10-05 WO disclosed