Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 8/20 | 0.58 |
| ▸ | GRM6 | O15303 | 1/20 | 0.57 |
| ▸ | GRM3 | Q14832 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4662147 | 0.90 | GRM2 (0.50) | GRM2GRM6GRM3 | |
| SCHEMBL5561558 | 0.90 | GRM2 (0.50) | GRM2GRM6GRM3 | |
| SCHEMBL5567019 | 0.90 | GRM2 (0.50) | GRM2GRM6GRM3 | |
| SCHEMBL4663771 | 0.90 | GRM2 (0.50) | GRM2GRM6GRM3 | |
| SCHEMBL5562175 | 0.88 | GRM2 (0.49) | GRM2GRM6GRM3 | |
| SCHEMBL5567433 | 0.88 | GRM2 (0.49) | GRM2GRM6GRM3 | |
| SCHEMBL4663811 | 0.88 | GRM2 (0.49) | GRM2GRM6GRM3 | |
| SCHEMBL4663666 | 0.88 | GRM2 (0.49) | GRM2GRM6GRM3 | |
| SCHEMBL5567527 | 0.88 | GRM2 (0.49) | GRM2GRM6GRM3 | |
| SCHEMBL5562977 | 0.85 | GRM2 (0.46) | GRM2GRM6GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703218-A1 | Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-03-27 | — | — | EP | disclosed |
| WO-1996005828-A1 | PYRROLIDINYL DI-CARBOXYLIC ACID DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-02-29 | — | — | WO | disclosed |