SCHEMBL8973088

SCHEMBL8973088

CCCCCCCCCCC1CCC(/C=C/C2CCC(c3ccc(C#N)c(F)c3)CC2)CC1

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 1/20 0.35
MAPT P10636 2/20 0.33
GAA P10253 1/20 0.33
SPHK1 Q9NYA1 3/20 0.33
CYP2C9 P11712 1/20 0.32
KDM1A O60341 4/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C8 P10632 1/20 0.32
S1PR3 Q99500 1/20 0.32
CHEK1 O14757 1/20 0.32
PGR P06401 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
MEN1 O00255 1/20 0.31
MAPK1 P28482 1/20 0.31
KMT2A Q03164 1/20 0.31
AR P10275 1/20 0.31
ENPP2 Q13822 1/20 0.31
FASN P49327 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8972331 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9
SCHEMBL8973421 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9
SCHEMBL8973095 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9
SCHEMBL8973416 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9
SCHEMBL8972888 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9
SCHEMBL8973463 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9
SCHEMBL8972139 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9
SCHEMBL8972119 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9
SCHEMBL8972876 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9
SCHEMBL8973428 1.00 GRM2 (0.35) GRM2MAPTGAASPHK1CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0588291-B1 2-Fluorobenzonitrile derivative CHISSO CORP (JP) 1996-03-27 EP disclosed
US-5370822-A Liquid crystals CHISSO CORPORATION (JP) 1994-12-06 US disclosed
EP-0588291-A1 2-Fluorobenzonitrile derivative Chisso Corporation (JP) 1994-03-23 EP disclosed