SCHEMBL8973352

SCHEMBL8973352

C=CCCc1ccc(CCc2ccc(O)cc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.64
ESR2 Q92731 2/20 0.64
LTA4H P09960 1/20 0.52
CA2 P00918 1/20 0.50
ALDH1A1 P00352 3/20 0.48
ADRA2A P08913 3/20 0.48
SLC6A2 P23975 3/20 0.48
KDM4E B2RXH2 2/20 0.48
HTR1A P08908 1/20 0.48
CYP2C19 P33261 1/20 0.48
HTR3A P46098 1/20 0.48
BACE1 P56817 1/20 0.48
TAAR1 Q96RJ0 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
BLM P54132 1/20 0.46
KMT2A Q03164 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
OPRM1 P35372 2/20 0.44
OPRD1 P41143 2/20 0.44
OPRK1 P41145 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL109430 0.98 ESR1 (0.59) ESR1ESR2LTA4HCA2ALDH1A1
SCHEMBL17847899 0.91 ESR1 (0.52) ESR1ESR2LTA4HCA2ALDH1A1
SCHEMBL6285109 0.88 GFER (0.41) ESR1ESR2LTA4HALDH1A1KDM4E
SCHEMBL9004469 0.85 GFER (0.36) ESR1ESR2CA2ALDH1A1KDM4E
SCHEMBL109815 0.84 ESR1 (0.54) ESR1ESR2LTA4HCA2ALDH1A1
SCHEMBL8973350 0.83 ESR1 (0.55) ESR1ESR2CA2ALDH1A1ADRA2A
SCHEMBL3100617 0.83 ESR1 (0.53) ESR1ESR2CA2ALDH1A1ADRA2A
SCHEMBL10908422 0.82 ESR1 (0.64) ESR1ESR2LTA4HCA2ALDH1A1
SCHEMBL3112000 0.81 ESR1 (0.57) ESR1ESR2CA2ALDH1A1ADRA2A
SCHEMBL3113234 0.81 ESR1 (0.57) ESR1ESR2CA2ALDH1A1ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0545409-B1 Liquid crystals with end groups containing more than one silane group CONSORTIUM ELEKTROCHEM IND (DE) 1996-03-06 EP disclosed
US-5399290-A Liquid crystals with (polysila) alkyl wing groups CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1995-03-21 US disclosed
EP-0545409-A1 Liquid crystals with end groups containing more than one silane group Consortium für elektrochemische Industrie GmbH (DE) 1993-06-09 EP disclosed