Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 7/20 | 1.00 |
| ▸ | GRM6 | O15303 | 1/20 | 0.76 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.64 |
| ▸ | GRM5 | P41594 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8972917 | 1.00 | GRM2 (1.00) | GRM2GRM6GRM3GRM5 | |
| SCHEMBL8973322 | 0.92 | GRM2 (0.85) | GRM2GRM6GRM3GRM5 | |
| SCHEMBL8972938 | 0.91 | GRM2 (0.83) | GRM2GRM6GRM3GRM5 | |
| SCHEMBL8973271 | 0.90 | GRM2 (0.81) | GRM2GRM6GRM3GRM5 | |
| SCHEMBL8973264 | 0.86 | GRM6 (1.00) | GRM2GRM6GRM3GRM5 | |
| SCHEMBL8061968 | 0.86 | GRM6 (1.00) | GRM2GRM6GRM3GRM5 | |
| SCHEMBL8973013 | 0.80 | GRM6 (0.87) | GRM2GRM6GRM3GRM5 | |
| SCHEMBL8973200 | 0.79 | GRM2 (0.65) | GRM2GRM6GRM3 | |
| SCHEMBL5566282 | 0.79 | GRM6 (0.75) | GRM2GRM6GRM3GRM5 | |
| SCHEMBL8972526 | 0.78 | GRM2 (1.00) | GRM2GRM6GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703218-A1 | Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-03-27 | — | — | EP | disclosed |
| WO-1996005828-A1 | PYRROLIDINYL DI-CARBOXYLIC ACID DERIVATIVES AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-02-29 | — | — | WO | disclosed |