Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.32 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8976082 | 1.00 | MEN1 (0.53) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8976085 | 1.00 | MEN1 (0.53) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8976491 | 0.91 | CYP2D6 (0.62) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8751267 | 0.91 | CYP2D6 (0.62) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8751300 | 0.91 | CYP2D6 (0.62) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9062853 | 0.91 | CYP2D6 (0.62) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8751270 | 0.91 | CYP2D6 (0.62) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL8976321 | 0.91 | CYP2D6 (0.62) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9062847 | 0.91 | CYP2D6 (0.62) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL9062551 | 0.85 | MEN1 (0.47) | MEN1KMT2ACYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500418-A | ANTIEPILEPTIC | CIBA-GEIGY CORPORATION (US) | 1996-03-19 | — | — | US | disclosed |
| US-5376684-A | Aminobutyric acid antagonist; antiepileptic agent | CIBA-GEIGY CORPORATION (US) | 1994-12-27 | — | — | US | disclosed |