Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.55 |
| ▸ | ENPEP | Q07075 | 5/20 | 0.51 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 11/20 | 0.51 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | NTSR2 | O95665 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8976242 | 1.00 | GRIN2D (0.55) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL30365494 | 0.97 | GRIN2D (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29375791 | 0.97 | GRIN2D (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29986050 | 0.97 | GRIN2D (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29988328 | 0.97 | GRIN2D (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL30483533 | 0.96 | GRIN2D (0.58) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL30974505 | 0.96 | GRIN2D (0.53) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL7591172 | 0.95 | GRIN2D (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL30401619 | 0.95 | GRIN2D (0.57) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL31563685 | 0.94 | GRIN2D (0.59) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512661-A | PROVIDES FOR NUCLEIC ACIDS ENCODING CHIMERIC NEUROTROPHIC FACTORS; FOR TARGETING ACTIVE COMPOUNDS TO CELLS RESPONSIVE TO NEUROTROPIC FACTOR | REGENERON PHARMACEUTICALS, INC. (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0542892-A4 | CHIMERIC NEUROTROPHIC FACTORS | — | 1993-11-10 | — | — | EP | disclosed |
| EP-0542892-A1 | CHIMERIC NEUROTROPHIC FACTORS | REGENERON PHARMACEUTICALS, INC. (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5169764-A | MULTITROPHIC AND MULTIFUNCTIONAL CHIMERIC NEUROTROPHIC FACTORS, AND NUCLEIC ACIDS AND PLASMIDS ENCODING THE CHIMERAS | REGENERON PHARMACEUTICALS, INC. (US) | 1992-12-08 | — | — | US | disclosed |
| WO-1992002620-A1 | CHIMERIC NEUROTROPHIC FACTORS | REGENERON PHARMACEUTICALS, INC. (US) | 1992-02-20 | — | — | WO | disclosed |