Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 14/20 | 0.63 |
| ▸ | KIF5B | P33176 | 6/20 | 0.63 |
| ▸ | KDR | P35968 | 6/20 | 0.61 |
| ▸ | EGFR | P00533 | 5/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6180170 | 0.80 | EGFR (0.76) | RETKIF5BKDREGFRFLT1 | |
| Hydrochloric Acid SCHEMBL6180124 | 0.79 | EGFR (0.74) | RETKIF5BKDREGFRFLT1 | |
| SCHEMBL8976490 | 0.78 | RET (0.65) | RETKIF5BKDREGFRFLT1 | |
| SCHEMBL8976518 | 0.77 | EGFR (0.76) | RETKIF5BKDREGFRFLT1 | |
| SCHEMBL8976474 | 0.77 | EGFR (0.66) | RETKIF5BKDREGFRFLT1 | |
| SCHEMBL8976454 | 0.77 | RET (1.00) | RETKIF5BKDR | |
| SCHEMBL12200787 | 0.77 | RET (0.74) | RETKIF5BKDREGFRFLT1 | |
| Hydrochloric Acid SCHEMBL8976418 | 0.76 | EGFR (0.67) | RETKIF5BKDREGFRFLT1 | |
| SCHEMBL5864594 | 0.76 | RET (1.00) | RETKIF5BKDREGFRFLT1 | |
| SCHEMBL5865250 | 0.76 | EGFR (1.00) | RETKIF5BKDREGFRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | claimed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | claimed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | claimed |
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |