Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 17/20 | 1.00 |
| ▸ | IP6K3 | Q96PC2 | 5/20 | 1.00 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871369 | 0.98 | IP6K1 (1.00) | IP6K1IP6K3IP6K2PIK3CDPIK3CA | |
| SCHEMBL8871230 | 0.87 | PIK3CD (0.80) | IP6K1IP6K3IP6K2PIK3CDPIK3CA | |
| SCHEMBL4869700 | 0.78 | PIK3CD (0.67) | IP6K1IP6K3IP6K2PIK3CDPIK3CA | |
| SCHEMBL4873411 | 0.78 | PIK3CD (0.67) | IP6K1IP6K3IP6K2PIK3CDPIK3CA | |
| SCHEMBL30169542 | 0.77 | PIK3CD (0.73) | IP6K1IP6K3IP6K2PIK3CDPIK3CA | |
| SCHEMBL4878824 | 0.77 | PIK3CD (0.73) | IP6K1IP6K3IP6K2PIK3CDPIK3CA | |
| SCHEMBL27517100 | 0.76 | IP6K1 (0.64) | IP6K1IP6K3PIK3CDPIK3CAPIK3CB | |
| SCHEMBL8976318 | 0.76 | IP6K1 (0.61) | IP6K1IP6K3IP6K2PIK3CDPIK3CA | |
| SCHEMBL4876138 | 0.75 | PIK3CD (0.71) | IP6K1IP6K3IP6K2PIK3CDPIK3CA | |
| SCHEMBL30823308 | 0.75 | PIK3CD (1.00) | IP6K1IP6K3IP6K2PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| CN-1094043-A | Quinazoline derivant | ZENECA LTD (GB) | 1994-10-26 | — | — | CN | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |