Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.65 |
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.63 |
| ▸ | EGFR | P00533 | 7/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26715240 | 0.83 | MKNK1 (0.67) | RETMKNK1EGFRKDRFLT1 | |
| Hydrochloric Acid SCHEMBL8976219 | 0.82 | MKNK1 (0.66) | RETMKNK1EGFRKDRFLT1 | |
| SCHEMBL29516907 | 0.81 | EGFR (0.74) | RETMKNK1EGFRKDRFLT1 | |
| SCHEMBL2835747 | 0.81 | EGFR (0.74) | RETMKNK1EGFRKDRFLT1 | |
| SCHEMBL7536031 | 0.79 | MKNK1 (0.69) | RETMKNK1EGFRKDRFLT1 | |
| SCHEMBL7535210 | 0.79 | EGFR (0.71) | RETMKNK1EGFRKDRFLT1 | |
| SCHEMBL6181034 | 0.79 | RET (1.00) | RETMKNK1EGFRKDRFLT1 | |
| SCHEMBL7539318 | 0.78 | EGFR (0.69) | RETMKNK1EGFRKDRFLT1 | |
| SCHEMBL15923731 | 0.78 | MKNK1 (1.00) | RETMKNK1EGFRFLT1ERBB2 | |
| Hydrochloric Acid SCHEMBL6179218 | 0.78 | RET (0.98) | RETMKNK1EGFRKDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5580870-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1996-12-03 | — | — | US | disclosed |
| EP-0602851-B1 | Quinazoline derivatives | ZENECA LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0602851-A1 | Quinazoline derivatives | ZENECA LIMITED (GB) | 1994-06-22 | — | — | EP | disclosed |