Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL2963355 | 0.90 | SMN1; SMN2 (0.52) | TSHRMEN1KMT2ATHRBHTT | |
| Triethylene Glycol SCHEMBL2953129 | 0.90 | SMN1; SMN2 (0.52) | TSHRMEN1KMT2ATHRBHTT | |
| Malic Acid SCHEMBL2964150 | 0.88 | SMN1; SMN2 (0.54) | TSHRMEN1KMT2ATHRBHTT | |
| Triethylene Glycol SCHEMBL30580745 | 0.88 | SMN1; SMN2 (0.62) | TSHRMEN1KMT2ATHRBHTT | |
| Triethylene Glycol SCHEMBL28065453 | 0.88 | SMN1; SMN2 (0.62) | TSHRMEN1KMT2ATHRBHTT | |
| Diethylene Glycol Monoethyl Ether SCHEMBL2953116 | 0.87 | SMN1; SMN2 (0.52) | TSHRMEN1KMT2ATHRBHTT | |
| Diethylene Glycol Monoethyl Ether SCHEMBL9054038 | 0.87 | SMN1; SMN2 (0.52) | TSHRMEN1KMT2ATHRBHTT | |
| Triethylene Glycol SCHEMBL2953118 | 0.87 | SMN1; SMN2 (0.52) | TSHRMEN1KMT2ATHRBHTT | |
| Malic Acid SCHEMBL27714812 | 0.86 | SMN1; SMN2 (0.65) | TSHRMEN1KMT2ASMN1; SMN2MAPK1 | |
| Malic Acid SCHEMBL28182365 | 0.85 | SMN1; SMN2 (0.54) | MEN1KMT2ATHRBHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549616-B1 | METHOD OF CLEANING PRINTED CIRCUIT BOARDS USING WATER | MOTOROLA INC (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0549616-A4 | — | — | 1994-01-19 | — | — | EP | disclosed |
| EP-0549616-A1 | METHOD OF CLEANING PRINTED CIRCUIT BOARDS USING WATER. | MOTOROLA INC (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0486685-A4 | USE OF ORGANIC ACIDS IN LOW RESIDUE SOLDER PASTES | — | 1993-04-07 | — | — | EP | disclosed |
| EP-0486685-A1 | USE OF ORGANIC ACIDS IN LOW RESIDUE SOLDER PASTES | MOTOROLA, INC. (US) | 1992-05-27 | — | — | EP | disclosed |
| WO-1992005008-A1 | METHOD OF CLEANING PRINTED CIRCUIT BOARDS USING WATER | MOTOROLA, INC. (US) | 1992-04-02 | — | — | WO | disclosed |
| US-5092943-A | Dicarboxylic acid having electron withdrawing group as flux | MOTOROLA, INC. (US) | 1992-03-03 | — | — | US | disclosed |
| WO-1991017858-A1 | USE OF ORGANIC ACIDS IN LOW RESIDUE SOLDER PASTES | MOTOROLA, INC. (US) | 1991-11-28 | — | — | WO | disclosed |
| US-5064481-A | Malic acid flux | MOTOROLA, INC. (US) | 1991-11-12 | — | — | US | disclosed |