SCHEMBL8977528

SCHEMBL8977528

Nc1cc(-c2ccccc2)ccc1Oc1cccc(Oc2ccc(-c3ccccc3)cc2N)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.54
CYP2C9 P11712 2/20 0.54
CYP2C19 P33261 2/20 0.54
CYP3A4 P08684 2/20 0.54
GAA P10253 4/20 0.49
ALDH1A1 P00352 4/20 0.49
MAPT P10636 5/20 0.48
L3MBTL1 Q9Y468 2/20 0.48
NPSR1 Q6W5P4 1/20 0.48
HTT P42858 3/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
LMNA P02545 2/20 0.47
KDM4E B2RXH2 2/20 0.47
HPGD P15428 2/20 0.47
HSD17B10 Q99714 2/20 0.47
USP2 O75604 1/20 0.47
HSP90AA1 P07900 1/20 0.47
ALOX15 P16050 1/20 0.47
ALOX12 P18054 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31090802 0.93 CYP1A2 (0.62) CYP1A2CYP2C9CYP2C19CYP3A4GAA
SCHEMBL3789145 0.93 CYP1A2 (0.62) CYP1A2CYP2C9CYP2C19CYP3A4GAA
SCHEMBL25135228 0.92 MAOB (0.58) CYP1A2CYP2C9CYP2C19CYP3A4GAA
SCHEMBL30393884 0.91 CYP1A2 (0.61) CYP1A2CYP2C9CYP2C19CYP3A4GAA
SCHEMBL30393807 0.91 CYP1A2 (0.65) CYP1A2CYP2C9CYP2C19CYP3A4GAA
SCHEMBL3785409 0.86 CYP1A2 (0.56) CYP1A2CYP2C9CYP2C19CYP3A4GAA
SCHEMBL3784764 0.86 CYP3A4 (0.59) CYP1A2CYP2C9CYP2C19CYP3A4GAA
SCHEMBL25135225 0.84 NCOA1 (0.57) CYP1A2CYP2C9CYP2C19CYP3A4GAA
SCHEMBL5906230 0.84 GAA (0.64) CYP1A2CYP2C9CYP2C19CYP3A4GAA
SCHEMBL29003782 0.82 NCOA1 (0.47) CYP1A2CYP2C9CYP2C19CYP3A4GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5480965-A BASED ON A NOVEL DIAMINO COMPOUND DERIVED FROM BENZOPHENONE STRUCTURE; FIBER REINFORCEMENT MITSUI TOATSU CHEMICALS, INC. (JP) 1996-01-02 US disclosed