SCHEMBL8977708

SCHEMBL8977708

S=C1NCC(c2ccc(Cl)c(Cl)c2)S1

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 17/20 0.43
SLC6A3 Q01959 17/20 0.43
SLC6A4 P31645 11/20 0.41
CYP2D6 P10635 7/20 0.41
KCNH2 Q12809 6/20 0.41
NAT1 P18440 1/20 0.34
BACE1 P56817 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8977697 0.67 SLC6A2 (0.43) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2
SCHEMBL25262561 0.65 SLC6A2 (0.68) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2
SCHEMBL26017598 0.65 SLC6A2 (0.56) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2
SCHEMBL2844239 0.64 SLC6A2 (0.44) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2
Hydrochloric Acid SCHEMBL25268867 0.63 SLC6A2 (0.66) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2
SCHEMBL27332932 0.62 SLC6A2 (0.46) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2
SCHEMBL11381861 0.61 SLC6A2 (0.45) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2
SCHEMBL22411087 0.61 MAP2K1 (0.48) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2
SCHEMBL9870878 0.61 SLC6A2 (0.58) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2
SCHEMBL9275640 0.61 SLC6A2 (0.44) SLC6A2SLC6A3SLC6A4CYP2D6KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0378308-B1 Acrylate fungicides AGREVO UK LTD (GB) 1996-04-10 EP disclosed