Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 14/20 | 0.69 |
| ▸ | EDNRB | P24530 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7939668 | 0.88 | EDNRA (0.67) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7223284 | 0.83 | EDNRA (0.66) | EDNRAEDNRBTSHR | |
| SCHEMBL7857311 | 0.81 | EDNRA (1.00) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7715940 | 0.80 | EDNRA (0.58) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL7939548 | 0.76 | EDNRA (0.64) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| Bms-182874 SCHEMBL802730 | 0.76 | EDNRA (1.00) | EDNRAEDNRBKDM4EMEN1CYP3A4 | |
| SCHEMBL8890120 | 0.76 | EDNRA (1.00) | EDNRA | |
| SCHEMBL8060560 | 0.76 | EDNRA (1.00) | EDNRAEDNRB | |
| SCHEMBL8055637 | 0.76 | EDNRA (0.74) | EDNRA | |
| Bms-182874 SCHEMBL117150 | 0.75 | EDNRA (0.98) | EDNRAEDNRBKDM4EMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5514691-A | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin | IMMUNOPHARMACEUTICS, INC. (US) | 1996-05-07 | — | — | US | disclosed |